Let’s get one thing straight: wrinkles are unavoidable. “Wrinkles are produced by a variety of causes,” says dermatologist Kavita Mariwalla, MD, of New York. “Internal variables such as age and heredity, as well as exterior factors such as sun exposure, smoking, and pollution,” says the author. While wrinkles are never anything to be embarrassed by, if you want to smooth them out or prevent them from appearing in the first place, there are a few things you can do.

When it comes to selecting the finest wrinkle cream for you, the first thing you should think about is when you plan to apply it. If you’re going to use it before you start your day, one with SPF is a good idea, according to the American Academy of Dermatology.

Best Overall: Olay Regenerist Micro-Sculpting Cream

Since its release, this well-liked wrinkle treatment has received a lot of positive feedback. Its creamy texture, as well as its effects, belie its price tag. This cult-favorite cream is formulated with a mix of hyaluronic acid, amino-peptides, and niacinamide (vitamin B3) to hydrate, plump skin, raise surface cells, and help smooth the appearance of fine wrinkles. From the first day you apply it, you may observe wrinkles softening.

Best Budget: RoC Retinol Correxion Deep Wrinkle Night Cream

Make the most of your beauty sleep with this anti-aging lotion that contains retinol to help reduce the look of wrinkles as you sleep. It has been clinically shown to decrease the appearance of fine lines and wrinkles in just 12 weeks, according to the company.

Retinol, a vitamin A derivative, is a popular anti-aging substance that can help smooth out fine lines and wrinkles. Because retinol can induce sun sensitivity, it’s only suggested for use in the evenings, which is another reason why this night cream is a fantastic choice, especially when used with sunscreen throughout the day.

Runner-Up, Best Budget: Olay Total Effects Anti-Aging Fragrance-Free Moisturizer

These fragrance-free alternative promises to replenish hydration, level skin tone, enhance brightness, dramatically smooth fine lines and wrinkles, minimize the appearance of pores, and restore firmness, among other things. The vitamin-rich composition can assist to strengthen the skin barrier, nourishing and moisturizing it. Any skin type may benefit from its usage because it won’t clog pores, and the formula dries fast and provides a smooth finish, making it ideal for use before makeup or on its own.

Best Splurge: SkinCeuticals A.G.E. Interrupter

Advanced glycation end-products, or A.G.E., are an important element of the normal aging process. This best-selling lotion aims to help slow down the loss of suppleness in the skin while also increasing collagen levels to keep skin appearing plump. It’s made with a 30 percent proxylane content, 4 percent blueberry extract, and 0.2 percent phytosphingosine, and the manufacturer claims it may help reduce the look of wrinkles and restore firmness loss. This cream, according to Skinceuticals, also decreases skin thinning, enhances texture, and replenishes vital nutrients and water.

Best with Retinol: Dr. Dennis Gross Skincare Ferulic + Retinol Anti-Aging Moisturizer

Retinol is the gold standard in anti-aging, according to any doctor, therefore it’s a crucial element to search for if you want younger-looking skin. This moisturizer, which is suitable for all skin types, harnesses the power of—you guessed it—retinol, as well as other youth-boosting ingredients. Because retinol might irritate the skin.

However, retinol isn’t used alone in this formula; it’s combined with ferulic acid, which has antioxidant properties. Overall, the mixture can defend against free radicals, guard against sun damage, and brighten and minimize the appearance of black spots, which are another common aging indication.

Runner-Up, Best with Retinol: Shani Darden Skin Care Retinol Reform

Retinol, retinol, retinol, retinol, This mild yet powerful solution contains 2.2 percent encapsulated retinol, which delivers various anti-aging effects without the dryness and irritation that many other retinol products have. It promotes cell turnover and collagen synthesis, which improves the skin’s plumpness and tone. It also contains a little lactic acid content of 2%, which might aid to brighten the skin.

Best with Vitamin C: Sunday Riley C.E.O. Vitamin C Rich Hydration Cream

This daily moisturizer contains vitamin C, which can help combat symptoms of aging such as free radical damage, fine lines, and hyperpigmentation. The recipe also contains a natural beta hydroxy acid, which can aid to brighten the complexion and reduce the appearance of redness on the skin.

Best for Dull Skin: OLEHENRIKSEN Goodnight Glow Retin-ALT Sleeping Crème

Because retinol is so strong, some people can’t tolerate it, no matter how many ceramide- or moisturizing-containing products they use. However, retinol alternatives such as bakuchiol, which is derived from the Ayurvedic babchi plant, are now available that are less harsh on the skin—especially for first-timers. Retinol, on the other hand, can aid in skin cell turnover.

Overall, the cream may help to reduce indications of aging such as lines and wrinkles while also nourishing the skin and avoiding the negative side effects associated with retinol usage. It’s also mild enough to be used every night.

Best Night Cream: Algenist Genius Sleeping Collagen

While you sleep, your skin heals itself, and this lotion can help speed up the process. This buttery cream combats dryness, fine lines and wrinkles, and a lack of elasticity, so you can wake up with dewy, radiant skin. It includes vegan plant collagen, alguronic acid, Mary thistle plant, and ceramides, which can smooth and plump the skin, reduce symptoms of aging, and moisturize it.

Runner-Up, Best Night Cream: Obagi Hydrate Luxe

This cream was created by Obagi to operate with your circadian cycle, taking advantage of the fact that your skin’s regeneration and metabolic activities accelerate at night. Because the eight hours of sleep you’re (hopefully) receiving are optimum time for skincare, they created this cream with ingredients like shea butter, biomimetic peptides, and hydromanil to help you wake up looking refreshed and shining. The recipe aids in the formation of a barrier on your skin, allowing moisture to be captured and cell healing to take place.

Best Drugstore: Neutrogena Rapid Wrinkle Repair Regenerating Anti-Wrinkle Retinol Cream + Hyaluronic Acid

This cream, which has the greatest concentration of Neutrogena’s Accelerated Retinol SA, penetrates deep into the skin’s surface to reduce the appearance of deep wrinkles. The company says that it can show dramatically younger-looking skin in only a week. This wrinkle cream is highly moisturizing and gives your skin a smoother, more even tone. The cream also includes Glucose Complex and hyaluronic acid, which can help reduce the appearance of wrinkles by boosting the skin’s surface activity while hydrating and rejuvenating dull skin.

Best for Prevention: Caudalie Resveratrol Lift Face Lifting Soft Cream

Resveratrol has been found to help your skin’s defense system by fighting free radicals and inhibiting their formation, and there’s plenty of it in this lightweight lotion. The resveratrol used by Caudalie comes from their family’s vineyard in Bordeaux, France, Château Smith Haut Lafitte. It’s made from grapevine stems and is known for restoring apparent stiffness. Grapeseed oil, peptides, elastin, and hyaluronic acid are among the ingredients in the wrinkle lotion, which can help increase collagen and lift while moisturizing. Furthermore, the active compounds may make their way into the skin all day thanks to the unique delivery system’s time-release technology.

Best for Neck: Perricone MD Cold Plasma Plus+ Neck & Chest

Even the most dedicated skincare devotees occasionally overlook the skin around the neck and chest, which is why many individuals see symptoms of aging first in these sensitive places. With this light-as-air, whipped moisturizer, give your neck and chest the care they deserve and keep symptoms of aging at bay. It’s developed particularly for the neck and chest to reduce wrinkles, tighten skin, and level out skin tone.

The recipe uses alpha lipoic acid (ALA), a powerful natural antioxidant and fatty acid present in every cell of the human body, to reduce lines, wrinkles, and enlarged pores. Vitamin B3 and Candeia Tree Extract are also included, according to the manufacturer.

Best with Hyaluronic Acid: BeautyStat Cosmetics Universal Pro-Bio Moisture Boost Cream

Because of its calming feel and visible effects, this light as air moisturizer is fast becoming a fan favorite. The hyaluronic acid-rich composition aids in the binding of moisture to the skin. It also includes ceramides, pomegranate sterols, and the ancient ingredient ganoderma, which, according to the company, can help to reduce wrinkles and premature lines while also detoxifying the skin. It also works well under makeup, according to users. It’s a definite plus!

Best Organic: Eminence Organic Skin Care Bright Skin Moisturizer SPF 30

This plant-based solution moisturizes and protects the skin from the sun while also aiding in the brightening and fading of discoloration and increasing collagen synthesis. It contains a natural hydroquinone replacement, a complex including African potato and tara tree extracts, as well as strong antioxidants such as bearberry extract, Swiss Alpine Plant Extracts, licorice root, and their distinctive BioComplex (a booster of antioxidants, coenzyme Q10, and alpha-lipoic acid). Overall, the natural composition can help your skin regain its radiance.

Best for Sensitive Skin: LilyAna Naturals Retinol Cream Moisturizer

This cream can teach wrinkles who’s boss without drying out the skin since it’s made with a strong combination of hyaluronic acid, vitamin E, green tea, shea butter, jojoba oil, and—of course—retinol. It’s also supposed to be mild enough for delicate skin, however, if you’re new to retinol, you should start slowly.

The Final Word

The Olay Regenerist Micro-Sculpting Cream is a favorite and one of the best wrinkle treatments on the market. It’s also a budget-friendly option, but the RoC Retinol Wrinkle Correxion Deep Wrinkle Night Cream is a genuine standout if you want to save even more money. It uses retinol, which is perhaps the most effective wrinkle-fighting chemical available. (Here are some additional retinol-based lotions to look at.) The Perricone MD Cold Plasma Plus+ Neck & Chest is our greatest option for neck wrinkles—because yes, you can acquire creases below your chin, too.

What to Look for in an Anti-Aging Cream


These are the first over-the-counter anti-aging ingredients, according to Mariwalla, with a proven track record of stimulating collagen formation to help smooth fine lines and wrinkles.

Alpha-Hydroxy Acids

Alpha-Hydroxy Acids (AHAs) are a kind of fatty acid, this group of exfoliating acids not only helps to level out skin tone and texture, but one of them, glycolic acid, has some collagen-boosting properties as well.


According to Mariwalla, there’s a whole new category of peptides that assist with skin elasticity and firmness, both of which play a part in wrinkle development. Not to add that peptides are more tolerated and cause less sensitivity than the world’s retinoids and acids.

Vitamin C is a powerful antioxidant.

This vitamin is a triple threat, working as a protective antioxidant, a great skin brightener, and a collagen stimulator, which means smoother, less wrinkled skin.


Do wrinkle creams have any effect?

They will work if you pick the appropriate mix with some of the tried-and-true anti-aging components we listed, use it religiously, and have a little patience. It’s crucial to remember, however, that no matter what sort of wrinkle cream you use, you must apply sunscreen every day (with broad-spectrum SPF 30 protection or greater) to prevent UV damage from thwarting your wrinkle-fighting efforts.

When should you start using wrinkle cream, and how old should you be?

The age at which you begin to see wrinkles is primarily determined by the environmental and internal variables stated by Mariwalla. However, she believes that starting an anti-aging skincare routine, including a wrinkle cream, in your mid-20s is a smart idea.

What is the best way to apply wrinkle cream?

Mariwalla suggests putting a pea-size drop of retinoid-based cream on clean skin and dabbing it on your forehead, nose, chin, and cheeks. If the product you’re using doesn’t include retinoids, use a nickel-sized quantity.

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